Double-blind clinical trial of 5-hydroxytryptophan in a case of Lesch-Nyhan syndrome.

نویسندگان

  • C D Frith
  • E C Johnston
  • M H Joseph
  • R J Powell
  • R W Watts
چکیده

5-Hydroxytryptophan (5-HTP) treatment of a single case of Lesch-Nyhan syndrome showing compulsive self-mutilation, athetoid movements, and characteristic clinical biochemical picture was studied on a double-blind basis. 5-HTP or placebo was administered for seven fortnightly treatment blocks. 5-HTP produced a significant reduction of athetoid movement and a sedative effect but did not improve the patient's mood or reduce self-mutilation.

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عنوان ژورنال:
  • Journal of neurology, neurosurgery, and psychiatry

دوره 39 7  شماره 

صفحات  -

تاریخ انتشار 1976